Binding of Isaac Unlock guide

Binding of Isaac Unlock

Last Updated on 17 September, 2020

Binding of Isaac Unlock guide – Unlock all the bosses, characters, collectibles, achievements, tasks, endings and secrets (Wrath of the Lamb unlockables also included)

Binding of Isaac Unlock – Boss

How to unlock all the boss unlockables

  • A Radioactive Spider: Defeat Boss in Basement 2.
  • Spelunker: Defeat Boss in Caves 2.
  • The Womb: Defeat Boss in The Depths 2.
  • The Harbingers: Defeat Boss in The Depths 2.
  • A Cube of Meat Collectible: Defeat Boss in The Depths 2.
  • A Halo Collectible: Defeat Boss in The Depths 2 or The Womb 2 (use the Bible)
  • Monstro’s Tooth: Defeat all the bosses in the Basement.
  • Lil Chubby: Defeat all the bosses in the Caves.
  • Loki’s Horns: Defeat all the bosses in The Depths.
  • The Book of Revelations: Defeat any Harbinger and or Horseman.
  • Little Steven: Defeat Steven.
  • Little C.H.A.D: Defeat C.H.A.D or the Headless Horseman.
  • Little Gish: Defeat Gish.
  • A Lump Of Coal: Defeat Krampus.

Binding of Isaac Unlock – Ending

How to unlock all the ending unlockables

  • Judas: Defeat boss in The Womb 2 1st time
  • The Book Of Belial: Defeat boss in The Womb 2 for the 1st time
  • The Noose: Defeat boss in The Womb 2 2nd time
  • The Nail: Defeat boss in The Womb 2 3rd time
  • A Quarter: Defeat boss in The Womb 2 4th time
  • A Fetus In A Jar: Defeat boss in The Womb 2 5th time
  • Everything’s Terrible!: Defeat boss in The Womb 2 6th time
  • The Wafer: Defeat boss in The Womb 2 7th time
  • Money = Power: Defeat boss in The Womb 2 8th time
  • It Lives: Defeat boss in The Womb 2 9th time
  • ???: Defeat boss in The Womb 2 for the tenth time.
  • The Poop: Defeat boss in The Womb 2 10th time
  • The Relic: Defeat boss in The Womb 2 using Magdalene.
  • Sack Of Pennies: Defeat boss in The Womb 2 using Cain.
  • Robo-Baby: Defeat boss in The Womb 2 using Judas.
  • D6: Defeat boss in The Womb 2 using ???.
  • Razor Blade: Defeat boss in The Womb 2 using Eve.
  • Mom’s Knife: Defeat boss in Sheol using Isaac.
  • Guardian Angel: Defeat boss in Sheol using Magdalene.
  • Bomb Bag: Defeat boss in Sheol using Cain.
  • Monster Manuel: Defeat boss in Sheol using Judas.
  • Forget Me Now: Defeat boss in Sheol using ???.
  • Demon Baby: Defeat boss in Sheol using Eve.

Binding of Isaac Unlock – Tasks

How to unlock all the tasks unlockables

  • Magdalene: Have 7 heart containers in a single playthrough
  • Yum Heart: Have 7 heart containers in a single playthrough
  • Cain: Have 55 Coins at once
  • Lucky Foot: Have 55 Coins at once
  • Eve: 2 or more deals with the devil in one playthrough.
  • Dead Bird: 2 or more deals with the devil in one playthrough.
  • Super Bandage: Defeat four Harbingers and or Horsemen in a single playthrough.
  • Small Rock: Destroy 50 Rocks (multiple playthroughs)
  • The Bean: Destroy 50 Poops piles (multiple playthroughs)
  • Mr. Mega: Destroy 10 Tinted Rocks rocks (multiple playthroughs)
  • Mom’s Bottle Of Pills: Use 20 Blood Donation Machines (multiple playthroughs)
  • The Book Of Sin: Defeat all of the Seven Deadly Sins (multiple playthroughs)
  • The Gamekid: Visit 10 Arcades (multiple playthroughs)
  • The Necronomicon: Use the XIII Death Tarot Card 4 times (multiple playthroughs)
  • The Parasite: Collect 2 of these items in a single play: Bob’s Rotten Head, Brother Bobby, Dead Cat, Max’s Head, Tammy’s Head or also Dead Bird.
  • Shears: Die 100 times.
  • The Common Cold: Collect 2 of either Roid Rage, The Virus, and Growth Hormones in a single playthrough.
  • Mom’s Contacts: Collect Mom’s Eye and Mom’s Heels/Mom’s Lipstick/Mom’s Pad/Mom’s Bra
  • Something from the Future (Steven): Defeat bosses in The Basement 42 times.
  • Something Cute (C.H.A.D.): Finish The Caves 20 times.
  • Something Sticky (Gish): Finish The Depths 30 times.
  • Basement Boy: Clear the Basement without taking damage.
  • Spelunker Boy: Clear the Cave without taking damage.
  • Dark Boy: Clear The Depths without taking damage.
  • Mamas Boy: Clear the Womb without taking damage.
  • Golden God: Collect 131/132 original items (not Wrath of the Lamb)

Binding of Isaac Unlock –  Wrath of the Lamb

Ending Unlockables in Wrath of the Lamb

How to unlock all the ending unlockables in Wrath of the Lamb

  • Samson: Complete Depths 2 without taking 2 Treasure Room items
  • D20: Complete the Cathedral using Isaac.
  • Celtic Cross: Complete the Cathedral using Maggy
  • Abel: Complete the Cathedral using Cain.
  • Curved Horn: Complete the Cathedral using Judas.
  • Sacrificial Dagger: Complete the Cathedral using Eve.
  • Rainbow Baby: Complete the Cathedral using ???.
  • Bloody Lust: Complete Womb 2 using Samson.
  • Blood Rights: Complete Sheol using Samson.
  • Bloody Penny: Complete the Cathedral using Samson.
  • The Polaroid: Complete the Cathedral 6 times.
  • Isaac’s Head: Complete the Chest using Isaac.
  • Maggy’s Faith: Complete the Chest using Maggy.
  • Cain’s Eye: Complete the Chest using Cain
  • Judas’ Tongue: Complete the Chest using Judas
  • Eve’s Bird Foot: Complete the Chest using ???
  • ???’s Soul: Complete the Chest using Eve
  • Samson’s Lock: Complete the Chest using Samson

Challenge Rewards Unlockables in Wrath of the Lamb

How to unlock all the challenge rewards unlockables in Wrath of the Lamb

  • The Candle: Complete 1st Challenge
  • Lucky Toe: Complete 2nd Challenge
  • Burnt Penny: Complete 3rd Challenge
  • Guppy’s Tail: Complete 4th Challenge
  • Fish Head: Complete 5th Challenge
  • Epic Fetus: Complete 6th Challenge
  • Super Fan: Complete 7th Challenge
  • Spider Butt: Complete 8th Challenge
  • Counterfeit Penny: Complete 9th Challenge
  • Daddy’s Love: Complete 10th Challenge

Tasks Unlockables in Wrath of the Lamb

How to unlock all the tasks unlockables in Wrath of the Lamb

  • Guppy’s Hairball: Transform Isaac into a Cat.
  • Dad’s Key: Defeat ???.
  • A Forgotten Horseman: Destroy 30 Tinted Rocks
  • Something Icky!: Finish The Womb 16 times.
  • The Left Hand: Defeat Ultra Pride.
  • Platinum God: Collect 197/198 items in the game and also unlock all the secrets.

Binding of Isaac Unlock – Characters

How to unlock all the Characters unlockables

  • Judas: Defeat boss in The Womb 2 1st time
  • ???: Defeat boss in The Womb 2 for the tenth time.
  • Magdalene: Have 7 heart containers in a single playthrough
  • Cain: Have 55 Coins at once
  • Eve: 2 or more deals with the devil in one playthrough.
  • Samson: Complete Depths 2 without taking 2 Treasure Room items
  • Azazel: make three deals with the devil in one run
  • Lazarus: once the player has four or more soul hearts (or black hearts) at once during a run
  • Eden: defeat Mom’s Heart for the first time
  • The Lost: Videoguide below
  • Lilith: (DLC Afterbirth) defeat Greed Mode with Azazel
  • Keeper: (DLC Afterbirth) donate 1000 coins to the Greed machine
  • Apollyon: (DLC Afterbirth+) defeat Mega Satan for the first time
  • The Forgotten: (DLC Afterbirth+) Videoguide below

How to Unlock The Lost

Check this video guide and learn how to unlock The Lost, or check our unlock The Lost step by step

How to Unlock The Forgotten

Check this video guide and learn how to unlock The Forgotten, or check our unlock The Forgotten step by step

About Miguel Sancho 1556 Articles
Helping gamers with walkthroughs, guides, cheats & console commands and codes lists since 2005

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